This medication could possibly be habit-forming. When you feel that the medication is just not Doing work as well, never use much more than your prescribed dose. Call your medical professional for Guidance.
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Antihistamines: concomitant administration of codeine and antihistamines with sedative Homes might induce increased CNS despair and/or respiratory despair and/or hypotension.
The two medicines pose a danger of overdose and withdrawal, so it is vital to debate dosage and tapering with a physician.
Supplemental aid and monitoring may very well be essential when prescribing for individuals liable to opioid misuse.
No ample reports are executed in animals to find out whether or not acetaminophen and codeine have a possible for carcinogenesis or mutagenesis. No suitable reports are performed in animals to determine whether or not acetaminophen has a potential for impairment of fertility.
If opioid use is necessary for a protracted interval inside a pregnant female, advise the affected individual of the chance of neonatal opioid withdrawal syndrome and be sure that ideal procedure will probably be accessible.
Codeine is a centrally acting weak analgesic. Codeine exerts its effect by way of μ opioid receptors, Despite the fact that codeine has very low affinity for these receptors, and its analgesic outcome is due to its conversion to morphine.
This merchandise really should not be administered to people who definitely have Earlier exhibited hypersensitivity to codeine or acetaminophen.
This drugs has become prescribed for more info you only. Do not move it on to Other people. It may well damage them, regardless of whether their indications of disease are the same as yours.
Anti-arrhythmics: codeine delays the absorption of mexiletine. The analgesic action of codeine is likely being appreciably impaired by quinidine which impairs codeine metabolism.
These may very well be signs or symptoms of a significant issue identified as serotonin syndrome. Your threat could be bigger if You furthermore mght acquire specific other medicines that have an impact on serotonin degrees in Your system.
Antidepressants: The depressant consequences of opioid analgesics may very well be Increased by tricyclic antidepressants. MAOIs taken with pethidine are already connected to extreme CNS excitation or depression (together with hypertension or hypotension). While this has not been documented with codeine, it can be done that an identical conversation may well take place and therefore the usage of codeine must be prevented whilst the individual is taking MAOIs and for two months just after MAOI discontinuation.
Aged: Dosage ought to more info be lowered inside the aged exactly where There exists impairment of hepatic or renal perform.